Macbeth, the game?

Well done, it'd be interesting, but only as a good "Dune Messiah" game would be, where the goal is not to "win", but to defeat prophecy.

In any case, you have to be damn good to turn any tragedy into a game, because, by definition, you cannot win a tragedy. It's Macbeth, King Lear, and Othello, not "Malcom," "Edgar," and "Iago" (although, truth be told, Iago: The Game would be *awesome* --- psychological manipulation as a game genre).