Oh my goodness. I like this topic. People keep posting such good ones like Light and L and Harry and Luna and Mal and Inara.  And some of the ones I'm posting might have already been said.

I prolly would like to see Sloan and Izzie or Callie and anybody but George and McSteamy. I know she's gone but Shephard(McDreamy)and Hahn...

And maybe just maybe Bones and Booth...

Oooh and from Fringe...Oliva and Peter or Peter and Astrid or Olivia and Charlie.....or Astrid or Olivia (lol not really)

And Tuxedo Max/Darien with anyone but Sailor Moon/Usagi/Serena

The Doctor and Martha or Rose

And Spike and Angel would be too creepy.  Hrmmm maybe Fred (pre or post super powers) and Spike.  Connor and Cordelia was not right!  Angel and Cordy shoulda hooked up instead...ha ha Riley and Cordy would of been good.

I think that's all my brain can come up with.